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p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1
Chromosomal region maintenance 1 (CRM1) mediates p53 nuclear export. Although p53 SUMOylation promotes its nuclear export, the underlying mechanism is unclear. Here we show that tethering of a small, ubiquitin-like modifier (SUMO) moiety to p53 markedly increases its cytoplasmic localization. SUMO a...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Cell Biology
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3756925/ https://ncbi.nlm.nih.gov/pubmed/23825024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-10-0771 |
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