Synthesis, Fluorine-18 Radiolabeling, and Biological Evaluation of N-((E)-4-Fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4′-halophenyl)nortropanes: Candidate Radioligands for In Vivo Imaging of the Brain Dopamine Transporter with Positron Emission Tomography

The N-(E)-fluorobutenyl-3β-(para-halo-phenyl)nortropanes 9-12 were synthesized as ligands of the dopamine transporter (DAT) for use as (18)F-labeled positron emission tomography (PET) imaging agents. In vitro competition binding assays demonstrated that compounds 9-12 have a high affinity for the DA...

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Hlavní autoři: Stehouwer, Jeffrey S., Daniel, Lauryn M., Chen, Ping, Voll, Ronald J., Williams, Larry, Plott, Susan J., Votaw, John R., Owens, Michael J., Howell, Leonard, Goodman, Mark M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756492/
https://ncbi.nlm.nih.gov/pubmed/20597489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100269c
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