Setting clock speed in mammals: the CK1ε tau mutation in mice accelerates the circadian pacemaker by selectively destabilizing PERIOD proteins

The intrinsic period of circadian clocks is their defining adaptive property. To identify the biochemical mechanisms whereby casein kinase1 (CK1) determines circadian period in mammals, we created mouse null and tau mutants of Ck1 epsilon. Circadian period lengthened in CK1ε(−/−), whereas CK1εtau/ta...

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Detalhes bibliográficos
Main Authors: Meng, Qing-Jun, Logunova, Larisa, Maywood, Elizabeth S., Gallego, Monica, Lebiecki, Jake, Brown, Timothy M., Sládek, Martin, Semikhodskii, Andrei S., Glossop, Nicholas R.J., Piggins, Hugh D., Chesham, Johanna E., Bechtold, David A., Yoo, Seung-Hee, Takahashi, Joseph S, Virshup, David M., Boot-Handford, Raymond P., Hastings, Michael H., Loudon, Andrew S.I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756141/
https://ncbi.nlm.nih.gov/pubmed/18400165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.01.019
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