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C3d adjuvant activity is reduced by altering residues involved in the electronegative binding of C3d to CR2
The final degradation product of the complement protein C3, C3d, has been used as a molecular adjuvant to various antigens. Chimera proteins of the antigen and multiple copies of C3d were developed to test the adjuvant effect of this molecule. The main mechanism by which C3d enhances the immune resp...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3755894/ https://ncbi.nlm.nih.gov/pubmed/20064559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imlet.2009.12.022 |
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