C3d adjuvant effects are mediated through the activation of C3d-specific autoreactive T cells

Complement fragment C3d covalently attached to antigens enhances immune responses, particularly for antigens lacking T cell epitopes. Enhancement has been attributed to receptor cross-linking between complement receptor CR2 (CD21) and polysaccharide antigen to surface IgM on naïve B cells. Paradoxic...

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Detalhes bibliográficos
Publicado no:Immunol Cell Biol
Main Authors: De Groot, Anne S., Ross, Ted M., Levitz, Lauren, Messitt, Timothy J., Tassone, Ryan, Boyle, Christine M., Vincelli, Amber J., Moise, Leonard, Martin, William, Knopf, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323994/
https://ncbi.nlm.nih.gov/pubmed/25385064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2014.89
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