A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein

TIME SHIFT: A high-throughput cell-based screen identified a benzothiazole analogue, LH846, which induces period lengthening of the circadian rhythm. Affinity chromatography coupled with mass spectrometry and genomic analysis identified protein kinase CKIδ as the biological target of LH846 (see pict...

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Bibliografski detalji
Glavni autori: Lee, Jae Wook, Hirota, Tsuyoshi, Peters, Eric C., Garcia, Michael, Gonzalez, Rodolfo, Cho, Charles Y., Wu, Xu, Schultz, Peter G., Kay, Steve A.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755734/
https://ncbi.nlm.nih.gov/pubmed/21954091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201103915
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