A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein

TIME SHIFT: A high-throughput cell-based screen identified a benzothiazole analogue, LH846, which induces period lengthening of the circadian rhythm. Affinity chromatography coupled with mass spectrometry and genomic analysis identified protein kinase CKIδ as the biological target of LH846 (see pict...

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Bibliografiske detaljer
Main Authors: Lee, Jae Wook, Hirota, Tsuyoshi, Peters, Eric C., Garcia, Michael, Gonzalez, Rodolfo, Cho, Charles Y., Wu, Xu, Schultz, Peter G., Kay, Steve A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755734/
https://ncbi.nlm.nih.gov/pubmed/21954091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201103915
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