Effect of Stearic Acid on Enalapril Stability and Dissolution from Multiparticulate Solid Dosage Forms

Enalapril maleate (EM) is a widely used anti-hypertensive drug which is unstable when mixed with excipients. Enalaprilate and diketopiperazine (DPK) are the main degradation products of enalapril. The in situ preparation of enalapril sodium salt (NaE) has been used to improve drug stability in dosag...

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Main Authors: Cunha, Talita A., Serpa, Raphael C., de Oliveira, Ana Paula M., Nasser, Letícia N., de Freitas, Luis Alexandre P., Taveira, Stephania F., Diniz, Danielle G. A., Lima, Eliana M., Marreto, Ricardo N.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755139/
https://ncbi.nlm.nih.gov/pubmed/23897034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-013-0006-6
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