Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction

Shwachman-Diamond syndrome (SDS), a rare autosomal recessive disorder characterized by exocrine pancreatic insufficiency and hematopoietic dysfunction, is caused by mutations in the Shwachman-Bodian-Diamond syndrome (SBDS) gene. We created human pluripotent stem cell models of SDS by knock-down of S...

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Bibliografiske detaljer
Main Authors: Tulpule, Asmin, Kelley, James M., Lensch, M. William, McPherson, Jade, Park, In Hyun, Hartung, Odelya, Nakamura, Tomoka, Schlaeger, Thorsten M., Shimamura, Akiko, Daley, George Q.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755012/
https://ncbi.nlm.nih.gov/pubmed/23602541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.04.002
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