Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome

Deficiencies in the SBDS gene result in Shwachman-Diamond syndrome (SDS), an inherited bone marrow failure syndrome associated with leukemia predisposition. SBDS encodes a highly conserved protein previously implicated in ribosome biogenesis. Using human primary bone marrow stromal cells (BMSCs), ly...

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Autori principali: Austin, Karyn M., Gupta, Mohan L., Coats, Scott A., Tulpule, Asmin, Mostoslavsky, Gustavo, Balazs, Alejandro B., Mulligan, Richard C., Daley, George, Pellman, David, Shimamura, Akiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2263145/
https://ncbi.nlm.nih.gov/pubmed/18324336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33764
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