In Vitro and In Vivo Studies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi

Chagas disease affects more than 10 million people worldwide, and yet, as it has historically been known as a disease of the poor, it remains highly neglected. Two currently available drugs exhibit severe toxicity and low effectiveness, especially in the chronic phase, while new drug discovery has b...

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Dettagli Bibliografici
Autori principali: Soeiro, Maria de Nazaré Correia, de Souza, Elen Mello, da Silva, Cristiane França, Batista, Denise da Gama Jaen, Batista, Marcos Meuser, Pavão, Beatriz Philot, Araújo, Julianna Siciliano, Aiub, Claudia Alessandra Fortes, da Silva, Patrícia Bernardino, Lionel, Jessica, Britto, Constança, Kim, Kwangho, Sulikowski, Gary, Hargrove, Tatiana Y., Waterman, Michael R., Lepesheva, Galina I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754355/
https://ncbi.nlm.nih.gov/pubmed/23774435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00070-13
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