In Vitro and In Vivo Studies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi

Chagas disease affects more than 10 million people worldwide, and yet, as it has historically been known as a disease of the poor, it remains highly neglected. Two currently available drugs exhibit severe toxicity and low effectiveness, especially in the chronic phase, while new drug discovery has b...

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Main Authors: Soeiro, Maria de Nazaré Correia, de Souza, Elen Mello, da Silva, Cristiane França, Batista, Denise da Gama Jaen, Batista, Marcos Meuser, Pavão, Beatriz Philot, Araújo, Julianna Siciliano, Aiub, Claudia Alessandra Fortes, da Silva, Patrícia Bernardino, Lionel, Jessica, Britto, Constança, Kim, Kwangho, Sulikowski, Gary, Hargrove, Tatiana Y., Waterman, Michael R., Lepesheva, Galina I.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754355/
https://ncbi.nlm.nih.gov/pubmed/23774435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00070-13
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