The Polymorphic Linker Domain of pfmdr1 Is Associated with Resistance-Conferring Mutations in Plasmodium falciparum Populations from East and West Africa

Sequence variation in the asparagine/aspartate-rich domain of pfmdr1 in 215 isolates of Plasmodium falciparum from three African countries was compared with published data. The role of this domain in modulating antimalarial sensitivity has not been established. The pfmdr1 86Y allele was significantl...

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Bibliografiske detaljer
Main Authors: Okombo, John, Zongo, Issaka, Gadalla, Nahla, Bousema, Teun, Beshir, Khalid B., Roper, Cally, Hallett, Rachel, Ochola-Oyier, Lynette Isabella, Sutherland, Colin J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754354/
https://ncbi.nlm.nih.gov/pubmed/23836177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00455-13
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