Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells

The nephrotoxicity of polymyxins is a major dose-limiting factor for treatment of infections caused by multidrug-resistant Gram-negative pathogens. The mechanism(s) of polymyxin-induced nephrotoxicity is not clear. This study aimed to investigate polymyxin B-induced apoptosis in kidney proximal tubu...

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Autors principals: Azad, Mohammad A. K., Finnin, Ben A., Poudyal, Anima, Davis, Kathryn, Li, Jinhua, Hill, Prue A., Nation, Roger L., Velkov, Tony, Li, Jian
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754291/
https://ncbi.nlm.nih.gov/pubmed/23796937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02587-12
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