Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts

Mice deficient in Schnurri-3 (SHN3; also known as HIVEP3) display increased bone formation, but harnessing this observation for therapeutic benefit requires an improved understanding of how SHN3 functions in osteoblasts. Here we identified SHN3 as a dampener of ERK activity that functions in part do...

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Hlavní autoři: Shim, Jae-Hyuck, Greenblatt, Matthew B., Zou, Weiguo, Huang, Zhiwei, Wein, Marc N., Brady, Nicholas, Hu, Dorothy, Charron, Jean, Brodkin, Heather R., Petsko, Gregory A., Zaller, Dennis, Zhai, Bo, Gygi, Steven, Glimcher, Laurie H., Jones, Dallas C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754267/
https://ncbi.nlm.nih.gov/pubmed/23945236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69443
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