Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts

Mice deficient in Schnurri-3 (SHN3; also known as HIVEP3) display increased bone formation, but harnessing this observation for therapeutic benefit requires an improved understanding of how SHN3 functions in osteoblasts. Here we identified SHN3 as a dampener of ERK activity that functions in part do...

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Main Authors: Shim, Jae-Hyuck, Greenblatt, Matthew B., Zou, Weiguo, Huang, Zhiwei, Wein, Marc N., Brady, Nicholas, Hu, Dorothy, Charron, Jean, Brodkin, Heather R., Petsko, Gregory A., Zaller, Dennis, Zhai, Bo, Gygi, Steven, Glimcher, Laurie H., Jones, Dallas C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754267/
https://ncbi.nlm.nih.gov/pubmed/23945236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69443
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