Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts

Mice deficient in Schnurri-3 (SHN3; also known as HIVEP3) display increased bone formation, but harnessing this observation for therapeutic benefit requires an improved understanding of how SHN3 functions in osteoblasts. Here we identified SHN3 as a dampener of ERK activity that functions in part do...

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Detaylı Bibliyografya
Asıl Yazarlar: Shim, Jae-Hyuck, Greenblatt, Matthew B., Zou, Weiguo, Huang, Zhiwei, Wein, Marc N., Brady, Nicholas, Hu, Dorothy, Charron, Jean, Brodkin, Heather R., Petsko, Gregory A., Zaller, Dennis, Zhai, Bo, Gygi, Steven, Glimcher, Laurie H., Jones, Dallas C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754267/
https://ncbi.nlm.nih.gov/pubmed/23945236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69443
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