Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling

Congenital amegakaryocytic thrombocytopenia (CAMT) is caused by the loss of thrombopoietin receptor–mediated (MPL-mediated) signaling, which causes severe pancytopenia leading to bone marrow failure with onset of thrombocytopenia and anemia prior to leukopenia. Because Mpl(–/–) mice do not exhibit t...

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Main Authors: Hirata, Shinji, Takayama, Naoya, Jono-Ohnishi, Ryoko, Endo, Hiroshi, Nakamura, Sou, Dohda, Takeaki, Nishi, Masanori, Hamazaki, Yuhei, Ishii, Ei-ichi, Kaneko, Shin, Otsu, Makoto, Nakauchi, Hiromitsu, Kunishima, Shinji, Eto, Koji
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754238/
https://ncbi.nlm.nih.gov/pubmed/23908116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64721
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