Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein

We describe methods to improve the properties of soluble, cleaved gp140 trimers of the human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) for use in structural studies and as immunogens. In the absence of nonionic detergents, gp140 of the KNH1144 genotype, terminating at residu...

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Bibliographic Details
Main Authors: Klasse, Per Johan, Depetris, Rafael S., Pejchal, Robert, Julien, Jean-Philippe, Khayat, Reza, Lee, Jeong Hyun, Marozsan, Andre J., Cupo, Albert, Cocco, Nicolette, Korzun, Jacob, Yasmeen, Anila, Ward, Andrew B., Wilson, Ian A., Sanders, Rogier W., Moore, John P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754145/
https://ncbi.nlm.nih.gov/pubmed/23824824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01226-13
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