Immunological and Virological Analyses of Rhesus Macaques Immunized with Chimpanzee Adenoviruses Expressing the Simian Immunodeficiency Virus Gag/Tat Fusion Protein and Challenged Intrarectally with Repeated Low Doses of SIVmac

Human adenovirus (AdHu)-based candidate AIDS vaccine can provide protection from simian immunodeficiency virus (SIV) transmission and disease progression. However, their potential use may be limited by widespread preexisting immunity to the vector. In contrast, preexisting immunity to chimpanzee ade...

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Main Authors: Cervasi, Barbara, Carnathan, Diane G., Sheehan, Katherine M., Micci, Luca, Paiardini, Mirko, Kurupati, Raj, Tuyishime, Steven, Zhou, Xiang Yang, Else, James G., Ratcliffe, Sarah J., Ertl, Hildegund C. J., Silvestri, Guido
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2013
主題:
Vaccines and Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754116/
https://ncbi.nlm.nih.gov/pubmed/23804645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01456-13
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