Activated CD4(+)CCR5(+) T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques

An effective T-cell–based AIDS vaccine should induce strong HIV-specific CD8(+) T cells in mucosal tissues without increasing the availability of target cells for the virus. Here, we evaluated five immunization strategies that include Human adenovirus-5 (AdHu5), Chimpanzee adenovirus-6 (AdC6) or -7...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Carnathan, Diane G., Wetzel, Katherine S., Yu, Joana, Lee, S. Thera, Johnson, Brent A., Paiardini, Mirko, Yan, Jian, Morrow, Matthew P., Sardesai, Niranjan Y., Weiner, David B., Ertl, Hildegund C. J., Silvestri, Guido
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299179/
https://ncbi.nlm.nih.gov/pubmed/25550504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407466112
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