Activated CD4(+)CCR5(+) T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques

An effective T-cell–based AIDS vaccine should induce strong HIV-specific CD8(+) T cells in mucosal tissues without increasing the availability of target cells for the virus. Here, we evaluated five immunization strategies that include Human adenovirus-5 (AdHu5), Chimpanzee adenovirus-6 (AdC6) or -7...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Carnathan, Diane G., Wetzel, Katherine S., Yu, Joana, Lee, S. Thera, Johnson, Brent A., Paiardini, Mirko, Yan, Jian, Morrow, Matthew P., Sardesai, Niranjan Y., Weiner, David B., Ertl, Hildegund C. J., Silvestri, Guido
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299179/
https://ncbi.nlm.nih.gov/pubmed/25550504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407466112
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