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Latent HIV-1 Can Be Reactivated by Cellular Superinfection in a Tat-Dependent Manner, Which Can Lead to the Emergence of Multidrug-Resistant Recombinant Viruses

The HIV-1 latent reservoir represents an important source of genetic diversity that could contribute to viral evolution and multidrug resistance following latent virus reactivation. This could occur by superinfection of a latently infected cell. We asked whether latent viruses might be reactivated w...

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Autori principali: Donahue, Daniel A., Bastarache, Sophie M., Sloan, Richard D., Wainberg, Mark A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754111/
https://ncbi.nlm.nih.gov/pubmed/23804632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01165-13
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