Lack of Prophylactic Efficacy of Oral Maraviroc in Macaques despite High Drug Concentrations in Rectal Tissues

Maraviroc (MVC) is a potent CCR5 coreceptor antagonist that is in clinical testing for daily oral pre-exposure prophylaxis (PrEP) for HIV prevention. We used a macaque model consisting of weekly SHIV(162p3) exposures to evaluate the efficacy of oral MVC in preventing rectal SHIV transmission. MVC do...

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Autores principales: Massud, Ivana, Aung, Wutyi, Martin, Amy, Bachman, Shanon, Mitchell, James, Aubert, Rachael, Solomon Tsegaye, Theodros, Kersh, Ellen, Pau, Chou-Pong, Heneine, Walid, García-Lerma, J. Gerardo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754060/
https://ncbi.nlm.nih.gov/pubmed/23740994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01204-13
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