Pharmacokinetic profile of raltegravir, elvitegravir and dolutegravir in plasma and mucosal secretions in rhesus macaques

OBJECTIVES: Pharmacokinetic studies in animal models are important for assessing the prophylactic potential of antiretroviral drugs for HIV prevention. This study sought to identify clinically relevant doses of the marketed integrase inhibitors raltegravir, elvitegravir and dolutegravir in macaques...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Massud, Ivana, Martin, Amy, Dinh, Chuong, Mitchell, James, Jenkins, Leecresia, Heneine, Walid, Pau, Chou-Pong, García-Lerma, J. Gerardo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398473/
https://ncbi.nlm.nih.gov/pubmed/25630643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku556
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