Pharmacokinetic profile of raltegravir, elvitegravir and dolutegravir in plasma and mucosal secretions in rhesus macaques

OBJECTIVES: Pharmacokinetic studies in animal models are important for assessing the prophylactic potential of antiretroviral drugs for HIV prevention. This study sought to identify clinically relevant doses of the marketed integrase inhibitors raltegravir, elvitegravir and dolutegravir in macaques...

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Bibliografski detalji
Izdano u:J Antimicrob Chemother
Glavni autori: Massud, Ivana, Martin, Amy, Dinh, Chuong, Mitchell, James, Jenkins, Leecresia, Heneine, Walid, Pau, Chou-Pong, García-Lerma, J. Gerardo
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398473/
https://ncbi.nlm.nih.gov/pubmed/25630643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku556
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