Merkel Cell Polyomavirus Large T Antigen Disrupts Host Genomic Integrity and Inhibits Cellular Proliferation

Clonal integration of Merkel cell polyomavirus (MCV) DNA into the host genome has been observed in at least 80% of Merkel cell carcinoma (MCC). The integrated viral genome typically carries mutations that truncate the C-terminal DNA binding and helicase domains of the MCV large T antigen (LT), sugge...

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Bibliografiske detaljer
Main Authors: Li, Jing, Wang, Xin, Diaz, Jason, Tsang, Sabrina H., Buck, Christopher B., You, Jianxin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Transformation and Oncogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754048/
https://ncbi.nlm.nih.gov/pubmed/23760247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01216-13
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