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Phosphorylation of Merkel Cell Polyomavirus Large Tumor Antigen at Serine 816 by ATM Kinase Induces Apoptosis in Host Cells

Merkel cell carcinoma is a highly aggressive form of skin cancer. Merkel cell polyomavirus (MCV) infection and DNA integration into the host genome correlate with 80% of all Merkel cell carcinoma cases. Integration of the MCV genome frequently results in mutations in the large tumor antigen (LT), le...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Li, Jing, Diaz, Jason, Wang, Xin, Tsang, Sabrina H., You, Jianxin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340428/
https://ncbi.nlm.nih.gov/pubmed/25480786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.594895
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