The Oncogenic Small Tumor Antigen of Merkel Cell Polyomavirus Is an Iron-Sulfur Cluster Protein That Enhances Viral DNA Replication

Merkel cell polyomavirus (MCPyV) plays an important role in Merkel cell carcinoma (MCC). MCPyV small T (sT) antigen has emerged as the key oncogenic driver in MCC carcinogenesis. It has also been shown to promote MCPyV LT-mediated replication by stabilizing LT. The importance of MCPyV sT led us to i...

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Bibliographic Details
Published in:J Virol
Main Authors: Tsang, Sabrina H., Wang, Ranran, Nakamaru-Ogiso, Eiko, Knight, Simon A. B., Buck, Christopher B., You, Jianxin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719616/
https://ncbi.nlm.nih.gov/pubmed/26608318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02121-15
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