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Role of Immediate Early Protein ICP27 in the Differential Sensitivity of Herpes Simplex Viruses 1 and 2 to Leptomycin B

Leptomycin B (LMB) is a highly specific inhibitor of CRM1, a cellular karyopherin-β that transports nuclear export signal-containing proteins from the nucleus to the cytoplasm. Previous work has shown that LMB blocks herpes simplex virus 1 (HSV-1) replication in Vero cells and that certain mutations...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Park, Donglim, Lengyel, Joy, Rice, Stephen A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754045/
https://ncbi.nlm.nih.gov/pubmed/23740995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00633-13
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