A Single Amino Acid Substitution in the ICP27 Protein of Herpes Simplex Virus Type 1 Is Responsible for Its Resistance to Leptomycin B

Leptomycin B (LMB) is a specific inhibitor of Crm1-dependent nuclear export of proteins. The replication of herpes simplex virus (HSV) is normally highly sensitive to LMB; a resistant HSV variant, however, was isolated by serial passages of the virus. Analysis of marker transfer and viral DNA sequen...

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Detalhes bibliográficos
Main Authors: Murata, Takayuki, Goshima, Fumi, Koshizuka, Tetsuo, Takakuwa, Hiroki, Nishiyama, Yukihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114000/
https://ncbi.nlm.nih.gov/pubmed/11134317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.2.1039-1043.2001
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