A Single Amino Acid Substitution in the ICP27 Protein of Herpes Simplex Virus Type 1 Is Responsible for Its Resistance to Leptomycin B

Leptomycin B (LMB) is a specific inhibitor of Crm1-dependent nuclear export of proteins. The replication of herpes simplex virus (HSV) is normally highly sensitive to LMB; a resistant HSV variant, however, was isolated by serial passages of the virus. Analysis of marker transfer and viral DNA sequen...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Murata, Takayuki, Goshima, Fumi, Koshizuka, Tetsuo, Takakuwa, Hiroki, Nishiyama, Yukihiro
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC114000/
https://ncbi.nlm.nih.gov/pubmed/11134317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.2.1039-1043.2001
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares