A Single Amino Acid Substitution in the ICP27 Protein of Herpes Simplex Virus Type 1 Is Responsible for Its Resistance to Leptomycin B

Leptomycin B (LMB) is a specific inhibitor of Crm1-dependent nuclear export of proteins. The replication of herpes simplex virus (HSV) is normally highly sensitive to LMB; a resistant HSV variant, however, was isolated by serial passages of the virus. Analysis of marker transfer and viral DNA sequen...

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Vydáno v:	J Virol
Hlavní autoři:	Murata, Takayuki, Goshima, Fumi, Koshizuka, Tetsuo, Takakuwa, Hiroki, Nishiyama, Yukihiro
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2001
Témata:	Virus-Cell Interactions
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114000/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11134317/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.2.1039-1043.2001
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