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The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage

Clade 2.2 Eurasian-lineage H5N1 highly pathogenic avian influenza viruses (HPAIVs) were first detected in Qinghai Lake, China, in 2005 and subsequently spread through Asia, Europe, and Africa. Importantly, these viruses carried a lysine at amino acid position 627 of the PB2 protein (PB2 627K), a kno...

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Detalhes bibliográficos
Main Authors: Long, Jason S., Howard, Wendy A., Núñez, Alejandro, Moncorgé, Olivier, Lycett, Samantha, Banks, Jill, Barclay, Wendy S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753988/
https://ncbi.nlm.nih.gov/pubmed/23843645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01399-13
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