Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition

BACKGROUND AND PURPOSE: Calcium handling is known to be deranged in heart failure. Interventions aimed at improving cell Ca(2)(+) cycling may represent a promising approach to heart failure therapy. Istaroxime is a new luso-inotropic compound that stimulates cardiac contractility and relaxation in h...

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Hlavní autoři: Ferrandi, Mara, Barassi, Paolo, Tadini-Buoninsegni, Francesco, Bartolommei, Gianluca, Molinari, Isabella, Tripodi, Maria Grazia, Reina, Cristina, Moncelli, Maria Rosa, Bianchi, Giuseppe, Ferrari, Patrizia
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753840/
https://ncbi.nlm.nih.gov/pubmed/23763364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12278
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