Targeting survival pathways in chronic myeloid leukaemia stem cells

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder characterized by the presence of a fusion oncogene BCR-ABL, which encodes a protein with constitutive TK activity. The implementation of tyrosine kinase inhibitors (TKIs) marked a major advance in CML therapy; however, there are...

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Bibliografiske detaljer
Main Authors: Sinclair, A, Latif, A L, Holyoake, T L
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2013
Fag:
Emerging Therapeutic Aspects in Oncology Themed Section
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753830/
https://ncbi.nlm.nih.gov/pubmed/23517124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12183
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