Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival

Cancer stem cells (CSCs) are responsible for the initiation and maintenance of some types of cancer, suggesting that inhibition of these cells may limit disease progression and relapse. Unfortunately, few CSC-specific genes have been identified. Here, we determined that the gene encoding arachidonat...

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Autores principales: Chen, Yaoyu, Peng, Cong, Abraham, Sheela A., Shan, Yi, Guo, Zhiru, Desouza, Ngoc, Cheloni, Giulia, Li, Dongguang, Holyoake, Tessa L., Li, Shaoguang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151200/
https://ncbi.nlm.nih.gov/pubmed/25105362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66129
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