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DNA-damage tolerance mediated by PCNA•Ub fusions in human cells is dependent on Rev1 but not Polη
In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue, leading to two modes of DNA-damage tolerance, namely, translesion DNA synthesis (TLS) and error-free lesion bypass. Although the majority of reported data sup...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3753651/ https://ncbi.nlm.nih.gov/pubmed/23761444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt542 |
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