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Constitutive fusion of ubiquitin to PCNA provides DNA damage tolerance independent of translesion polymerase activities
In response to replication-blocking DNA lesions, proliferating cell nuclear antigen (PCNA) can be conjugated with a single ubiquitin (Ub) or Lys63-linked Ub chains at the Lys164 residue, leading to two modes of DNA damage tolerance (DDT), namely translesion synthesis (TLS) and error-free DDT, respec...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2926605/ https://ncbi.nlm.nih.gov/pubmed/20385585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq239 |
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