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Structure-function analysis of the 5′ end of yeast U1 snRNA highlights genetic interactions with the Msl5•Mud2 branchpoint-binding complex and other spliceosome assembly factors
Yeast pre-mRNA splicing initiates via formation of a complex comprising U1 snRNP bound at the 5′ splice site (5′SS) and the Msl5•Mud2 heterodimer engaged at the branchpoint (BP). Here, we present a mutational analysis of the U1 snRNA, which shows that although enlarging the 5′ leader between the TMG...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3753624/ https://ncbi.nlm.nih.gov/pubmed/23754852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt490 |
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