Loading...

Defining essential elements and genetic interactions of the yeast Lsm2–8 ring and demonstration that essentiality of Lsm2–8 is bypassed via overexpression of U6 snRNA or the U6 snRNP subunit Prp24

A seven-subunit Lsm2–8 protein ring assembles on the U-rich 3′ end of the U6 snRNA. A structure-guided mutational analysis of the Saccharomyces cerevisiae Lsm2–8 ring affords new insights to structure–function relations and genetic interactions of the Lsm subunits. Alanine scanning of 39 amino acids...

Full description

Saved in:
Bibliographic Details
Published in:RNA
Main Authors: Roth, Allen J., Shuman, Stewart, Schwer, Beate
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959253/
https://ncbi.nlm.nih.gov/pubmed/29615482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.066175.118
Tags: Add Tag
No Tags, Be the first to tag this record!