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Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels
Kv11.1 channels are critical for the maintenance of a normal heart rhythm. The flow of potassium ions through these channels is controlled by two voltage-regulated gates, termed “activation” and “inactivation,” located at opposite ends of the pore. Crucially in Kv11.1 channels, inactivation gating o...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3753607/ https://ncbi.nlm.nih.gov/pubmed/23980196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201310975 |
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