A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb

Voltage-gated sodium channels undergo slow inactivation during repetitive depolarizations, which controls the frequency and duration of bursts of action potentials and prevents excitotoxic cell death. Although homotetrameric bacterial sodium channels lack the intracellular linker-connecting homologo...

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Autores principales: Gamal El-Din, Tamer M., Martinez, Gilbert Q., Payandeh, Jian, Scheuer, Todd, Catterall, William A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753604/
https://ncbi.nlm.nih.gov/pubmed/23980192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311012
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