Cannabinoid Receptor 2 Signaling in Peripheral Immune Cells Modulates Disease Onset and Severity in Mouse Models of Huntington's Disease

Peripheral immune cells and brain microglia exhibit an activated phenotype in premanifest Huntington's disease (HD) patients that persists chronically and correlates with clinical measures of neurodegeneration. However, whether activation of the immune system contributes to neurodegeneration in...

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Hlavní autoři: Bouchard, Jill, Truong, Jennifer, Bouchard, Kristofer, Dunkelberger, Diana, Desrayaud, Sandrine, Moussaoui, Saliha, Tabrizi, Sarah J., Stella, Nephi, Muchowski, Paul J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753072/
https://ncbi.nlm.nih.gov/pubmed/23238740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4008-12.2012
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