Elevated Cerebrospinal Fluid Lactate Concentrations in Patients with Bipolar Disorder and Schizophrenia: Implications for the Mitochondrial Dysfunction Hypothesis

BACKGROUND: Evidence is accumulating that mitochondrial dysfunction is involved in the pathophysiology of bipolar disorder and schizophrenia. Cerebrospinal fluid (CSF) concentration of lactate, a product of extra-mitochondrial glucose metabolism, is commonly elevated in individuals with mitochondria...

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Bibliographic Details
Main Authors: Regenold, William T., Phatak, Pornima, Marano, Christopher M., Sassan, Amritpal, Conley, Robert R., Kling, Mitchel A.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752997/
https://ncbi.nlm.nih.gov/pubmed/19103439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2008.11.010
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