Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis

Although evidence for mitochondrial dysfunction in the pathogenesis of bipolar disorder (BD) has been reported, the precise biological basis remains unknown, hampering the search for novel biomarkers. In this study, we performed metabolomics of cerebrospinal fluid (CSF) from male BD patients (n=54)...

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Detalles Bibliográficos
Publicado en:Mol Psychiatry
Main Authors: Yoshimi, N, Futamura, T, Bergen, S E, Iwayama, Y, Ishima, T, Sellgren, C, Ekman, C J, Jakobsson, J, Pålsson, E, Kakumoto, K, Ohgi, Y, Yoshikawa, T, Landén, M, Hashimoto, K
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078854/
https://ncbi.nlm.nih.gov/pubmed/26782057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.217
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