Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis

Although evidence for mitochondrial dysfunction in the pathogenesis of bipolar disorder (BD) has been reported, the precise biological basis remains unknown, hampering the search for novel biomarkers. In this study, we performed metabolomics of cerebrospinal fluid (CSF) from male BD patients (n=54)...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Psychiatry
Auteurs principaux: Yoshimi, N, Futamura, T, Bergen, S E, Iwayama, Y, Ishima, T, Sellgren, C, Ekman, C J, Jakobsson, J, Pålsson, E, Kakumoto, K, Ohgi, Y, Yoshikawa, T, Landén, M, Hashimoto, K
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078854/
https://ncbi.nlm.nih.gov/pubmed/26782057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.217
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