Ouabain Protects against Shiga Toxin–Triggered Apoptosis by Reversing the Imbalance between Bax and Bcl-xL

Hemolytic uremic syndrome, a life-threatening disease often accompanied by acute renal failure, usually occurs after gastrointestinal infection with Shiga toxin 2 (Stx2)–producing Escherichia coli. Stx2 binds to the glycosphingolipid globotriaosylceramide receptor, expressed by renal epithelial cell...

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Bibliographic Details
Main Authors: Burlaka, Ievgeniia, Liu, Xiao Li, Rebetz, Johan, Arvidsson, Ida, Yang, Liping, Brismar, Hjalmar, Karpman, Diana, Aperia, Anita
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2013
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752948/
https://ncbi.nlm.nih.gov/pubmed/23744887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012101044
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