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Conditional Deletion of Histone Deacetylase-4 in the Central Nervous System Has No Major Effect on Brain Architecture or Neuronal Viability
Evidence from different laboratories using cell culture and in vivo model systems indicates that histone deacetylase-4 (HDAC4) plays an essential role in maintaining neuronal survival. Indeed, HDAC4 null knockout mice, which die within 2 weeks of birth, display cerebellar degeneration, whereas RNAi-...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752780/ https://ncbi.nlm.nih.gov/pubmed/23239283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.23170 |
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