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Histone Deacetylase-1 (HDAC1) Is a Molecular Switch between Neuronal Survival and Death
Both neuroprotective and neurotoxic roles have previously been described for histone deacetylase-1 (HDAC1). Here we report that HDAC1 expression is elevated in vulnerable brain regions of two mouse models of neurodegeneration, the R6/2 model of Huntington disease and the Ca(2+)/calmodulin-dependent...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3471765/ https://ncbi.nlm.nih.gov/pubmed/22918830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.394544 |
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