Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice

We examined the effects of a natural secondary bile acid, hyodeoxycholic acid (HDCA), on lipid metabolism and atherosclerosis in LDL receptor-null (LDLRKO) mice. Female LDLRKO mice were maintained on a Western diet for 8 wk and then divided into 2 groups that received chow, or chow + 1.25% HDCA, die...

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Detalhes bibliográficos
Main Authors: Shih, Diana M., Shaposhnik, Zory, Meng, Yonghong, Rosales, Melenie, Wang, Xuping, Wu, Judy, Ratiner, Boris, Zadini, Filiberto, Zadini, Giorgio, Lusis, Aldons J.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752541/
https://ncbi.nlm.nih.gov/pubmed/23752203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-223008
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