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The synergistic inhibition of atherogenesis in apoE(−/−) mice between pravastatin and the sPLA(2) inhibitor varespladib (A-002)

Secretory phospholipase A2 (sPLA(2)) activity promotes foam cell formation, increases proinflammatory bioactive lipid levels, decreases HDL levels, increases atherosclerosis in transgenic mice, and is an independent marker of cardiovascular disease. The effects of the sPLA(2) inhibitor A-002 (varesp...

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Detalhes bibliográficos
Main Authors: Shaposhnik, Zory, Wang, Xuping, Trias, Joaquim, Fraser, Heather, Lusis, Aldons J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656655/
https://ncbi.nlm.nih.gov/pubmed/19029066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800361-JLR200
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