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The synergistic inhibition of atherogenesis in apoE(−/−) mice between pravastatin and the sPLA(2) inhibitor varespladib (A-002)
Secretory phospholipase A2 (sPLA(2)) activity promotes foam cell formation, increases proinflammatory bioactive lipid levels, decreases HDL levels, increases atherosclerosis in transgenic mice, and is an independent marker of cardiovascular disease. The effects of the sPLA(2) inhibitor A-002 (varesp...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2656655/ https://ncbi.nlm.nih.gov/pubmed/19029066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800361-JLR200 |
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