Differential targeting of IL-2 and T cell receptor signaling pathways selectively expands regulatory T cells while inhibiting conventional T cells

Strategies to expand regulatory T cells hold therapeutic potential for ameliorating T cell-mediated autoimmunity. Recently, we reported that the requirements for T cell receptor signaling in conventional T cell and regulatory T cell proliferation are different. Using mutant mice that display defecti...

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Main Authors: Satake, Atsushi, Schmidt, Amanda M, Archambault, Angela, Leichner, Theresa M, Wu, Gregory F, Kambayashi, Taku
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752416/
https://ncbi.nlm.nih.gov/pubmed/23834842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2013.06.009
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