Transforming Growth Factor–β Signaling in Hepatocytes Promotes Hepatic Fibrosis and Carcinogenesis in Mice With Hepatocyte-Specific Deletion of TAK1

BACKGROUND & AIMS: Transforming growth factor (TGF)-β–activated kinase 1 (TAK1) is activated in different cytokine signaling pathways. Deletion of Tak1 from hepatocytes results in spontaneous development of hepatocellular carcinoma (HCC), liver inflammation, and fibrosis. TGF-β activates TAK1 an...

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Hlavní autoři: YANG, LING, INOKUCHI, SAYAKA, ROH, YOON SEOK, SONG, JINGYI, LOOMBA, ROHIT, PARK, EEK JOONG, SEKI, EKIHIRO
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752402/
https://ncbi.nlm.nih.gov/pubmed/23391818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.01.056
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